Systems Integration

Investigating 'life' via metabolic flux and bioenergetic analyses

SAHUTCHAI INWONGWAN (GLA), DPhil

Scientist • Biologist • Biochemist

Lecturer in Systems Biology, BIOL, CMU, Thailand
Honorary Research Fellow, GEE, UCL, UK

image

Sahutchai completed a DPhil (PhD) degree from the Department of Plant Sciences, University of Oxford. His thesis explored the capacities of Euglena metabolic network using metabolic flux analysis techniques. He was working as a research fellow at University College London before moving back to Chiang Mai, Thailand, for his lectureship in Systems biology.

Our current research focuses include:

- Metabolic modelling and network optimisation of Euglena gracilis for sustainable industrial and advanced applications

- Physicochemical and metabolic processes in fermented beverage

- Astrobiochemistry, modelling the optimal network for extraterrestrial conditions

- Investigating multi-layer physiological effects of mito-nuclear incompatibilities in Drosophila

- Astrobioinovation, physiology of various organisms in space analog conditions and its application

- Multi-omics analysis in PM2.5 exposed lung cancer cells

- Metabolic modelling of honey bee gut microbime

image

Key Skills

Research

Ethanol-driven mixotrophic cultivation enhances biomass production and CO2 capture in Euglena gracilis for sustainable bioresource utilisation, 2025 Inwongwan, S., Duangjan, K., Sensupa, P., Phinyo, K., Ruangrit, K., Pumas, C., & Pekkoh, J. Algal Research, 104148. https://doi.org/10.1016/j.algal.2025.104148

Acute PM2.5 Exposure in Distinct NSCLC Cell Lines Reveals Strong Oxidative Stress and Therapy Resistance Signatures Through Transcriptomic Analysis, 2025 Panya, A., Thongyim, S., Sattayawat, P., & Inwongwan, S. Toxics, 13(6), 484. https://doi.org/10.3390/toxics13060484

Metabolomic Insights into the Adaptations and Biotechnological Potential of Euglena gracilis Under Different Trophic Conditions, 2025 Inwongwan, S.*, Sriwari, S., & Pumas, C. Plants, 14(11), 1580. https://doi.org/10.3390/plants14111580

Comparative Analysis of Physicochemical and Biological Activities of Meads from Five Mekong Region Honeys Pre- and Post-Fermentation, 2025 Inwongwan, S., Kitcharoen, T., Wongsasuk, P., Le Masurier, W., Saksunwiriya, C., Takioawong, P., Pandith, H., Intarasit, S., Noirungsee, N., & Disayathanoowat, T. Fermentation, 11(4), 190. https://doi.org/10.3390/fermentation11040190

Metabolic response and gene expression changes induced by local PM2.5 exposure in non-small cell lung cancer cells, 2023 - ongoing Funded by National Research Council of Thailand (Fundamental Fund), PI: Sahutchai Inwongwan Department of Biology, Faculty of Science, Chiang Mai University

Developing metabolic model of Euglena for beta-glucan production optimisation, 2023 - ongoing Funded by National Research Council of Thailand (Fundamental Fund), PI: Sahutchai Inwongwan Department of Biology, Faculty of Science, Chiang Mai University

Enhancing carbon capture and biomass production of Euglena using mixotrophic metabolic processes with high redox potential substrates, 2023 - ongoing Funded by The Murata Science Foundation (MSF), , PI: Sahutchai Inwongwan Department of Biology, Faculty of Science, Chiang Mai University

Unlocking the potential of Euglena gracilis as a host for production of shikimate-derived products through integrated metabolic modelling, 2023 - ongoing Funded by National Research Council of Thailand, PI: Sahutchai Inwongwan Department of Biology, Faculty of Science, Chiang Mai University

Exploring the metabolic potential and applications of Williamsia marianensis using genome-scale metabolic model, 2023 - ongoing Funded by Chiang Mai University, PI: Sahutchai Inwongwan Department of Biology, Faculty of Science, Chiang Mai University

Microalgae growth-promoting bacteria for cultivation strategies: Recent updates and progress, 2024 Pathom-aree, W., Sattayawat, P., Inwongwan, S., Cheirsilp, B., Liewtrakula, N., Maneechote, W., Rangseekaew, P., Ahmad, F., Mehmood, M. A., Gao, F. & Srinuanpan, S Microbiological Research, https://doi.org/10.1016/j.micres.2024.127813

Engineering Gut Symbionts: A Way to Promote Bee Growth?, 2024 Sattayawat P. , Inwongwan S. , Noirungsee N. , Li, J. , Guo, J. , Disayathanoowat, T Insects, https://doi.org/10.3390/insects15050369

Distinct fungal microbiomes of two Thai commercial stingless bee species, Lepidotrigona terminata and Tetragonula pagdeni suggest a possible niche separation in a shared habitat, 2024 Castillo D.C. , Sinpoo C. , Phokasem P. , Yongsawas R. , Sansupa C. , Attasopa K. , Suwannarach N. , Inwongwan S. , Noirungsee N. , Disayathanoowat T. Frontiers in Cellular and Infection Microbiology, https://doi.org/10.3389/fcimb.2024.1367010

Genome‐scale metabolic modelling of extremophiles and its applications in astrobiological environments, 2024 Noirungsee, N., Changkhong, S., Phinyo, K., Suwannajak, C., Tanakul, N. and Inwongwan, S
Environmental Microbiology Reports, https://doi.org/10.1111/1758-2229.13231

Mitonuclear interactions modulate nutritional preference, 2024 Camus, M.F. and Inwongwan, S. Biology Letters, 19(12), p.20230375, https://doi.org/10.1098/rsbl.2023.0375

Harmonising protocols to measure Drosophila respiratory function in mitochondrial preparations, 2023 Enrique Rodríguez, Stefano Bettinazzi, Sahutchai Inwongwan, M. Florencia Camus, Nick Lane MitoFit Preprints, 2023.4 https://doi.org/10.26124/mitofit:2023-0004

Metabolic network reconstruction of Euglena gracilis: Current state, challenges, and applications, 2023 INWONGWAN, S., PEKKOH, J., PUMAS, C. & SATTAYAWAT, P Frontiers in Microbiology, https://doi.org/10.3389/fmicb.2023.1143770

Flux Capacitor: How mitochondria modulate metabolic flux and gene expression, 2020 - ongoing Funded by BBSRC, UK, PI: Prof. Nick Lane Genetics, Evolution & Environment, Devision of Biosciences, University College London

Metabolic flux analysis in Euglena gracilis, 2020 Supervisors: Prof. Dr. George Ratcliffe, Dr. Nick Kruger and Dr. Ellis O’Neill Department of Plant Sciences, University of Oxford

Euglena central metabolic pathways and their subcellular locations, 2019 Sahutchai Inwongwan, Nicholas J. Kruger, R. George Ratcliffe and Ellis C. O’Neill Metabolites 2019, 9(6), 115; https://doi.org/10.3390/metabo9060115

Interspecific interaction between marine Chrysochromulina spp. and their associated bacteria, 2015 Advisor: Prof. Dr. Rose Ann Cattolico, University of Washington Funded by Development and Promotion of Science and Technology talents project (DPST)

Isolation and cultivation of Botryococcus braunii Kützing for hydrocarbon production, 2015 Advisor: Asst. Dr. Jeeraporn Pekkoh Funded by Junior Science Talent Project (JSTP), NSTDA

Experiences

o Research Fellow, University College London, Study the effect of mito-nuclear incompatibility in Drosophila, UK, 2020-2022

o Policy development intern, National Science Research and Innovation Policy Council, Developing BCG Economy Model, Thailand, 2019

o Biological practice demonstrator, University of Oxford UK, 2017-2020

o Research internship, Biological Modelling Laboratory, KMUTT, Train for systems biology, metabolic network analysis and bioinformatics skills, Thailand, 2016

o Research internship, Cattolico Laboratory, University of Washington, Study interaction of bacteria and algae for growth and lipid production, USA, 2014

o JENESYS 2.0 program, science and technology, Government of Japan, Japan, 2014

o Visiting Israel on the topic of precision agriculture, Academic collaboration between Israel and Thailand, Funded by : National Science and Technology Development (NSTDA), Israel, 2013

o Visiting Shanghai on the topic of agricultural biotechnology, Visit universities and research institutes in Shanghai for research collaborations between research institutes in Thailand and Shanghai, Funded by : Ministry of Foreign Affairs, Kingdom of Thailand, China, 2012

o Internship, National Center for Genetic Engineering and Biotechnology, Study gene expression in cassava root, Thailand, 2012

Contact

SAHUTCHAI INWONGWAN, DPhil
Lecturer in Systems Biology
Room BB2406
Department of Biology, Faculty of Science
Chiang Mai University
239 Huay Keaw Rd, Tambon Su Thep, Mueang District
Chiang Mai, Thailand, 50200
email: sahutchai.inwongwan@cmu.ac.th, s.inwongwan@ucl.ac.uk
Tel: +66 821972128

Art projects

unnamed-5 Hugging Gourd, GLA, London, April 2021

image Winner of Research SNAPSHOT, Oxford Biochemical Society Magazine 2017